When machine learning algorithms key in on auxiliary features of this sort, they may do well at analyzing images exactly like the ones they were trained on, but they will not be able to generalize effectively to other contexts. John Zech and colleagues at California Pacific Medical Center wanted to investigate how well neural networks could detect pathologies such as pneumonia and cardiomegaly—enlarged heart—using X-ray images. The team found that their algorithms performed relatively well in hospitals where they were trained, but poorly elsewhere. It turned out that the machine was cueing on
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