Increased cellular omega-6 levels cause an increase in inflammation (contributing to a range of Western diseases). Increased inflammation (via TNF-alpha) leads to poorer functioning of insulin and a dulling of the effect of leptin (the hormone produced by fat cells that keeps us thin). Poorer insulin function means that more insulin is required within the blood. Higher levels of insulin also result in a dulling of the leptin signal. All these effects result in a rise in the weight set-point and then, inevitably … weight gain.
