In planning upstream interventions, we’ve got to look outside the lines of our own work. Zoom out and pan from side to side. Are we intervening at the right level of the system? And what are the second-order effects of our efforts: If we try to eliminate X (an invasive species or a drug or a process or a product), what will fill the void? If we invest more time and energy in a particular problem, what will receive less focus as a result, and how might that inattention affect the system as a whole?