Drip some SCFAs onto L cells, and they start churning out PYY and GLP-1. You can do this in a petri dish1228 or in a person, either by infusing their rectums with an SCFA enema1229 or the old-fashioned way of feeding people fiber1230 or, even better, fiber-rich foods.1231 These hormones then get released into the bloodstream where they can shoot right up into the appetite center of the brain and turn down our cravings.1232
