Neuroscientists describe endocannabinoids as the “don’t worry, be happy” chemical, which gives us our first clue about what exactly an exercise high does to your brain. Areas of the brain that regulate the stress response, including the amygdala and prefrontal cortex, are rich in receptors for endocannabinoids. When endocannabinoid molecules lock into these receptors, they reduce anxiety and induce a state of contentment. Endocannabinoids also increase dopamine in the brain’s reward system, which further fuels feelings of optimism. As runner Adharanand Finn observes, “It may only be chemicals
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