Next-Generation Biomaterials for Bone & Periodontal Regeneration

by Richard J Miron

The ideal grafting material should therefore (1) contain osteogenic progenitor cells within the bone grafting scaffold capable of depositing new bone matrix, (2) demonstrate osteoinductive potential by recruiting and inducing mesenchymal stem cells (MSCs) to differentiate into mature bone-forming osteoblasts, and (3) provide a scaffold that facilitates 3D tissue ingrowth.

These included the ability of an osteoinductive material to (1) recruit mesenchymal osteoprogenitor cells (MSCs), (2) induce