In 2016, Japanese biologist Yoshinori Ohsumi closed his Nobel lecture ominously: “Truly original discoveries in science are often triggered by unpredictable and unforeseen small findings. . . . Scientists are increasingly required to provide evidence of immediate and tangible applications of their work.” That is head start fervor come full circle; explorers have to pursue such narrowly specialized goals with such hyperefficiency that they can say what they will find before they look for it.