Each and every medical or nursing student is taught repeatedly that these lifesaving drugs can cause depression and increase fatigue. Turns out that if you look at the data from clinical trials, beta-blockers don’t cause any more fatigue than the placebo and, in fact, improve depression and depressive symptoms.42 Yet most patients who are started on a beta-blocker are warned of these two symptoms, increasing the chances that they will go on to experience them.

