People with bipolar disorder experience episodes of depression when their mood is abnormally low and episodes of mania when it’s too high. The latter is associated with high levels of dopamine, which shouldn’t be surprising given the symptoms of the manic state: high energy, euphoric mood, racing thoughts that quickly jump from one topic to another, an abundance of activity in pursuit of many goals at once, and excessive involvement in high-risk, pleasure-seeking activities such as unrestrained spending and promiscuous sexual behavior.