Older antipsychotic medications don’t do this very well. They stick hard to the receptor. If something interesting happens and dopamine spikes, tough luck. The medication has latched on so tight, no dopamine can get through, and that doesn’t feel good. Being cut off from natural dopamine surges makes the world a dull place and makes it hard to find reasons to get out of bed in the morning. Newer drugs bind more loosely. A surge of dopamine knocks the drug off the receptors, and the this is interesting feeling gets through.
