In an essay for Oprah.com, writer Ada Calhoun described the way many women even in their thirties and forties feel adrift, like they’re misleading their lives. One of her friends, forty-one, told her, “Sometimes, I have these moments of clarity, usually during lengthy conference calls,” she said. “This voice in my head suddenly starts shouting: What are you doing? This is pointless and boring! Why aren’t you out there doing something you love?”