At moments of intense emotional distress Jefferson often suffered what he would call an “attack of my periodical headache,” a migraine headache so debilitating and vicious that he once said he was “obliged to avoid reading, writing, and almost thinking.”6,7 Before 1776, his last known bout had come in the wake of his heartbreak over Rebecca Burwell. With the death of Jane Randolph Jefferson, the blood and nerves in his brain gave him nothing but anguish. The force of her death was almost more than he could stand. The pain would not stop.
