the rate of developing colon cancer is consistently lower for women, especially premenopausal women, suggesting that estrogen protects against the growth of cancerous cells in the colon.15 Over the decades, numerous researchers have found that women who take HRT in pill form (as opposed to the transdermal patch) have a lower risk of getting colon cancer and a lower mortality rate from colon cancer if they do get it as compared with women not on hormones.