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In one early study, for example, Gould and her colleagues found that removing the ovaries of adult female rats—which caused levels of circulating estrogen to plummet—resulted in a profound decrease in the number of dendrites on neurons in the rats’ hippocampi. When they gave the rats estrogen, with or without progesterone, after removing the ovaries, this decrease did not occur.
Estrogen Matters: Why Taking Hormones in Menopause Can Improve Women's Well-Being and Lengthen Their Lives -- Without Raising the Risk of Breast Cancer (2024 Revised and Updated Edition)
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