—In 1991, cardiologist Lee Goldman and statistician Anna Tosteson, both then at Harvard Medical School, wrote a lead editorial for the New England Journal of Medicine titled “Uncertainty About Postmenopausal Estrogen: Time for Action, Not Debate.” A consensus of epidemiological studies, they wrote, had shown that women who were given postmenopausal estrogen had a 40 to 50 percent reduction in the risk of coronary artery disease compared with women who had not taken hormones.11