Although the WISDOM study found no alleviation of symptoms of depression among the participants, two randomized trials of estrogen therapy reported remarkable success. Women suffering from depressive episodes received four to twelve weeks of estrogen or placebo. Those in the estrogen group had a 60 to 75 percent improvement versus a 20 to 30 percent improvement for women given placebo.27 That estrogen was so much better than antidepressants, and without the side effects antidepressants often have,28 should have been big news.
