The FDA continues to require an ominous black box on every estrogen product, warning of “cardiovascular disease, probable dementia, and breast cancer.” And yet the WHI investigators now say that estrogen does not increase deaths from heart disease and cancer. On the contrary, it increases longevity, most notably when begun within ten years of the last menstrual period. HRT is the best preventive for osteoporotic hip fractures. It is safe and effective when applied vaginally for local symptoms. And, in the most striking about-face from their 2003 headlines that HRT “did not have a clinically
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