The Countdown on Calories Is a calorie a calorie? Almost all diet doctors will tell you that your weight is based on “calories in and calories out.” They will tell you that the first law of thermodynamics states that, in a closed system, you can’t make or destroy energy. (We measure energy by calories.) However, it has been misinterpreted to mean that the only key issues for weight loss are calorie intake versus calorie burning. But it is not that simple. First, the human body is not a closed system. Our metabolism is very complicated. Even our gut microbiome can influence how much of our food
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