If we are indeed bringing famine, plague and war under control, what will replace them at the top of the human agenda? Like firefighters in a world without fire, so humankind in the twenty-first century needs to ask itself an unprecedented question: what are we going to do with ourselves? In a healthy, prosperous and harmonious world, what will demand our attention and ingenuity? This question becomes doubly urgent given the immense new powers that biotechnology and information technology are providing us with. What will we do with all that power?