And we now know why. Our facial expressions are hardwired5 into our emotions: we can’t have one without the other. Botox lessens depression because it prevents us from making sad faces. But it also dampens our connection to those around us because we feel empathy by mimicking each other’s facial expressions. With Botox, mimicry becomes impossible, so we feel almost nothing at all. No wonder Nicole Kidman was relieved to get a few wrinkles back.