Liberalism inaugurated a transformation in the natural and human sciences and humanity’s relationship to the natural world. The first wave of this revolution—inaugurated by early-modern thinkers dating back to the Renaissance—insisted that man should employ natural science and a transformed economic system to seek mastery of nature. The second wave—developed largely by various historicist schools of thought, especially in the nineteenth century—replaced belief in the idea of a fixed human nature with belief in human “plasticity” and capacity for moral progress.