“Ask not what your country can do for you. Ask what you can do for your country.” Marc told me that if you want to understand how to think about the origins of depression, and how they relate to the brain, in a more truthful way than we’ve been taught to for the last few decades, it helps to know something the psychologist W. M. Mace said years ago, riffing on JFK: “Ask not what’s inside your head,”9 he said. “Ask what your head’s inside of.”