people with IR who eat high-carb diets (more than 50 grams per day), whether associated with T2DM or not, produces a collection of grave secondary consequences:66 Weight gain Increased fat in the abdominal organs (visceral adiposity) High blood pressure Abnormal blood fat, glucose and insulin concentrations (atherogenic dyslipidaemia – Table 16.3 on page 314) Elevated blood uric-acid concentrations (gout) Impaired ability of arteries to dilate (endothelial dysfunction) Whole-body inflammation Dysfunction of the mitochondria (cellular organs that produce energy) Progressive increases in IR
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