Lore of Nutrition: Challenging conventional dietary beliefs

by Tim Noakes

of uric acid by an enzyme called AMP deaminase, which is present in all cells, but is of particular importance in the liver.109 He then found that fructose activates this enzyme. Thus, Johnson’s theory is that the fructose in sugar increases uric acid production, which switches susceptible humans into hibernation mode, producing hyperphagia (overeating due to increased hunger), IR, and elevated blood glucose, insulin and triglyceride concentrations, leading to fat accumulation in the liver and fat cells. He believes that it is the increase in sugar consumption over the past 50 to 100 years that is the single most important driver of the IR/metabolic syndrome/obesity/T2DM epidemics. The case against sugar, begun by Cleave, Campbell and Yudkin, has now become mainstream.