By measuring the amount of fat in the livers of people with different metabolic conditions, including T2DM and NAFLD, Fernando Brill and his colleagues at the University of Florida have established that it is the presence of NAFLD, and not the overall level of body fatness, that predicts the presence of atherogenic dyslipidaemia.35 Their work therefore establishes that it is IR and NAFLD, and not obesity per se, that produces the abnormal metabolic state (atherogenic dyslipidaemia) that causes heart disease in those with IR and the related metabolic syndrome. The following are the metabolic
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