400 mcg is where you have a transcendental or mystical experience. At this dose or higher, it is critical to have qualified supervision in the form of a guide. “Transcendental” here roughly means “the feeling or the awareness that you are connected not only to other people but to other things and to living systems.” More on this later. 200 mcg can be used for psychotherapy, self-exploration, deep inner work, and healing. 100 mcg is useful for creative problem solving with non-personal matters (e.g., physics, biomechanics, or architecture). A number of Nobel Prize laureates in chemistry,
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