Ever-creative Homo sapiens had long fought back against disease with quackery such as prayer, sacrifice, bloodletting, cupping, toxic metals, homeopathy, and squeezing a hen to death against an infected body part. But starting in the late 18th century with the invention of vaccination, and accelerating in the 19th with acceptance of the germ theory of disease, the tide of battle began to turn. Handwashing, midwifery, mosquito control, and especially the protection of drinking water by public sewerage and chlorinated tap water would come to save billions of lives.

