The FHA manual was perhaps the single most detrimental document in the history of urbanism in the United States. With a few lines of anti-density, racist planning policy, the federal government essentially forced the creation of the suburbs and the near-complete disinvestment of the inner city.
I think this is very strong. It seems to be the center of a majority of our racial redlining, car-centric culture problems, and utter waste perpetrated across major areas.