A shortened telomere can sit inside an aging cell for months, signaling and signaling for help but not allowing the cell to take action to resolve the damage. This unremitting but futile signaling can have devastating consequences. Because now that cell becomes like the rotten apple in the barrel. It starts affecting all the tissues around it. The SASP process involves chemicals like proinflammatory cytokines that, over time, travel through the body, leading to system-wide chronic inflammation. Judith Campisi of the Buck Institute of Aging discovered SASP, and she has shown that these cells
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