Even if the network components or their connectivity has not been disrupted, pathophenotypes or endopathophenotypes may operate in parts of the dynamic range discrete from the physiological state. Here again, the central role of a defined stimulus to elicit (and organize) a measured response can be appreciated. Without a series of calibrated stimulus–response pairs that traverse the different network states from organogenesis to adulthood or from a timescale of microseconds to decades, it may be difficult even to detect an abnormal disease network.
