Recent work has suggested that Tau has multiple functions (Morris and Maeda 2011), with possibly distinct functions at different places in the neuron, and that it should be seen in terms of an integrated system whereby Tau and its interaction partners are anchored spatially together (Hashiguchi and Hashiguchi 2013) or even considered as parts of one single molecular machine composed of a finite number of biomolecules (Juhàsz et al. 2011).
