A variety of other computational methods have been developed to analyze GWAS results within a network context, including Network Interface Miner for Multigenic Interactions (NIMMI) (Akula, Baranova, et al. 2011), Disease Association Protein-Protein Link Evaluator (DAPPLE) (Rossin, Lage, et al. 2011), and NetworkMiner (Garcia-Alonso, Alonso, et al. 2012). These genetic-network approaches assume that genetic association studies and protein–protein interaction networks offer complementary information regarding a complex disease. These methods have provided strong evidence that protein products of
...more
