In addition, it requires that one can distinguish among three types of network modules: topological, or modules that are defined purely by proximity of nodes to one another; functional, or modules that comprise nodes with common functional consequences, often acting through a common pathway; and disease, or modules that reflect altered functional consequences owing to changes in the behavior of a (mutant) node, the loss of a links between normally functioning nodes, or the development of new links between nodes leading to novel, dysfunctional module activities (Figure 6–3).
