Chen and colleagues performed multiple -omics analysis in blood samples from a single individual repeatedly over more than 1 year of observation. In addition to performing whole-genome DNA sequencing, they obtained repeated assessments of transcriptomics (using RNA-seq), proteomics (including autoantibody profiles), and metabolomics, thus creating an integrative personal -omics profile (iPOP) (Chen, Mias, et al. 2012).
