The striking similarity between leptin deficiency and starvation suggested that low leptin levels might be responsible for the human brain’s response to starvation, including the hunger, the obsession with food, the activation of brain reward regions, and, as we will soon see, the reduced metabolic rate. It seemed as if the absence of leptin in leptin-deficient children prevented their brains from “seeing” their fat, triggering a powerful starvation response despite the fact that they had extreme obesity.
hmmm
