“He may have poisoned himself, in a way,” said Mary. She hesitated—would her idea sound foolish? Impossible? But she had to tell someone, and she had known Mrs. Poole as long as she could remember. Mrs. Poole had been like a mother to her, when her own mother couldn’t be. “These documents imply—they seem to indicate—that he was performing chemical experiments. On himself, and one of those experiments transformed him into Hyde. The disguise wasn’t just a physical change, like changing his clothes and putting on false hair, but an actual chemical transformation.”