The Way of the Iceman: How the Wim Hof Method Creates Radiant Long-term Health—Using the Science and Secrets of Breath Control, Cold-Training and Commitment

by Wim Hof

when Wim and his trained group were injected with endotoxin, a completely opposite reaction occurred. Their adrenaline levels rose immediately when they started their special breathing exercises. This activated CREB and made it dominant so the inflammatory proteins controlled by NF-kB remained at a low level, while proteins like IL-10—regulated by CREB—increased. As IL-10 also inhibits the inflammatory reaction, the inflammation was doubly inhibited.