On June 8, 2012, a sunny Friday afternoon, I clicked Confirm on my computer, formally submitting our paper for consideration to the journal Science. It would be published just twenty days later, on June 28, and nothing after that would ever be the same—not for me, not for my collaborators, and not for the field of biology. In that moment, however, my elation at this milestone was muted. I was more exhausted than I’d ever been in my life.