Emmanuelle and I, and our collaborators, had imagined that CRISPR technology could save lives by helping to cure genetic disease. Yet as I thought about it now, I could scarcely begin to conceive of all of the ways in which our hard work might be perverted. Overwhelmed by how fast everything was moving and by how quickly it seemed it could all go wrong, I began to feel a bit like Dr. Frankenstein. Had I created a monster?