the side effects of a medication typically cease once a patient stops taking the drug. With gene editing, however, any off-target DNA sequence, once edited, is irreversibly changed. Not only will unintended edits to the DNA be permanent, they will also be copied into every cell that descends from the first one. And although most random edits are unlikely to damage the cell, if we’ve learned anything from certain diseases and cancers, it’s that even a single mutation can be enough to wreak havoc on an organism.