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And with the newest and arguably most effective genetic engineering tool, CRISPR-Cas9 (CRISPR for short), the genome—an organism’s entire DNA content, including all its genes—has become almost as editable as a simple piece of text.
the chromosome. Similar
Specifically, he wanted to understand how two strands of DNA from one chromosome could merge with two matching strands of DNA from a second chromosome, exchange information during some kind of fused intermediate stage, and then separate again to re-form the individual chromosomes after cells divide.
came to be called phage therapy: the notion that bacteriophages could be used to treat bacterial infections. Although some
research conducted with ZFN and TALEN proteins, would be capable of editing the genome—any genome, not just one belonging to a bacterial virus. Out of this fifth bacterial weapons system, we had built the means to rewrite the code
And how miraculous, how fortunate, that we could repurpose this fundamental property for an entirely different use. It was a precious time of pure joy, the joy of discovery—a feeling just like I’d felt in Dr. Hemmes’s lab all those years before.
