Master Your T: The Definitive Guide to Raising Your Testosterone Naturally

by Christopher Walker

Neurons in the paraventricular nucleus of the hypothalamus synthesize and secrete vasopressin & CRH (corticotropin-releasing hormone). The release of these peptides stimulates the secretion of ACTH in the pituitary gland which acts to produce glucocorticoids (ie cortisol - synthesized from cholesterol) in the adrenal glands. These glucocorticoids now act back on the hypothalamus to suppress any more release of CRH & ACTH. This is what we refer to as a negative feedback loop. It regulates itself when everything is healthy and working properly. Keep in mind that the hypothalamus is only one of several targets in the brain for glucocorticoids. Stress hormones such as cortisol act on many different tissues and substrates within both your brain & your body - a big reason why keeping this feedback loop working properly is VITAL to maintaining a healthy body. One positive feedback loop within the HPA axis that you should be