In many ways, we’ve already reached the next level Schwartz is referring to. In fact, we’ve cured obesity countless times—in rodents. We now have the ability to take genes from almost any species, manipulate them to make them do what we want, insert them into the mouse genome so that they are expressed in specific cell populations of the brain, and use them to influence food intake, adiposity, and many other things. We can precisely activate, silence, or even kill specific populations of neurons in the mouse brain, controlling appetite and adiposity as if the mouse were a marionette. Modern
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really? i havent heard of any circuit-level manipulations that specifically reset the mtabolic setpoint.
