Eiduson’s research project isn’t the only one to reach this conclusion. Her colleagues looked at historical examples of long-term scientific achievers, such as Alexander Fleming and Louis Pasteur, and compared them to “one-hit wonders” such as James Watson, co-discoverer of DNA, and Jonas Salk, who developed the polio vaccine. They found the same pattern: Fleming and Pasteur switched research topics frequently; Watson and Salk did not.