Sexualized humiliation always enrages Snape. Perhaps Tobias Snape was disappointed in his bookish, unmanly son, and frequently said so. We have seen Snape’s response to James revealing his underwear and to students laughing at the thought of him dressed as an old lady. We see now that Lily knew this about him, which means that when he called her a Mudblood, her rejoinder about washing his pants was a pointed renunciation of her steadfast defenses of his appearance. If he was going to see her as the outside world did, instead of for her true self, she would make sure he understood that he broke
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