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“Couldn’t they hire someone temporary, you could take your sabbatical year with me, and then you could start?” “No.” “Did you even ask?”
“This isn’t your one shot. You’re brilliant, and you don’t have Alzheimer’s. You’re going to have plenty of shots.”
“This next year is my one shot, John, not yours. This next year is my last chance at living my life and knowing what it means to me. I don’t think I have much more time of really being me, and I want to spend that time with you, and I can’t believe you don’t want to spend it together.”
“I don’t think I can do it, Alice. I’m sorry, I just don’t think I can take being home for a whole year, just sitting and watching what this disease is stealing from you.
It kills me.” “No, John, it’s killing me, not you.
He opened the freezer and rummaged inside. “Do we have any chicken?” he asked. She didn’t answer. “Oh no, Alice.” He turned to show her something in his hands. It wasn’t chicken. “It’s your BlackBerry, it was in the freezer.”
“It looks like it got water in it, we can see after it’s thawed, but I think it’s dead,” he said. She burst into ready, heartbroken tears.
“It’s okay. If it’s dead, we’ll get y...
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Maybe the death of her organizer symbolized the death of her position at Harvard, and she was mourning the recent loss of her career. That also made sense. But what she felt was an inconsolable grief over the death of the BlackBerry itself.
“Okay, Alice, can you spell the word water backwards for me?” he asked.
More and more, she was experiencing a growing distance from her self-awareness.
“Good job,” said Dr. Davis. He smiled widely and seemed impressed. Alice liked him.
She’d said a tearful good-bye to okay some time ago.
“This is Harvard graduation,” said Alice.
“Who is this man?” asked Alice,
“He’s an actor,” said John.
He kept talking about a picaresque.
“It’s a long adventure that teaches the hero lessons.”
the lessons he’d learned along his way. He gave them five: Be creative, be useful, be practical, be generous, and finish big.
John sat at the end of a long table
and read The New York Times. He opened to the “Health” section first,
He read the first article on the page and cried openly as his coffee cooled. AMYLIX FAILS TRIAL
patients with mild to moderate Alzheimer’s disease who took Amylix during the fifteen-month trial failed to show a significant stabilization of dementia symptoms compared with placebo.
even the highest dose of Amylix failed to show improvement or stabilization as measured by the Alzheimer’s Disease Assessment Scale and scores on Activities of Daily Living, and they declined at a rate that was significant and expected.
The clinical trial drug Amylix, described in this book, is fictional. It is, however, similar to real compounds in clinical development that aim to selectively lower levels of amyloid-beta 42. Unlike the currently available drugs, which can only delay the disease’s ultimate progression, it is hoped that these drugs will stop the progression of Alzheimer’s.
