This, at least, is the way the body responds to physical activity. Scientists know much less about how the brain changes in response to mental challenges. One major difference between the body and the brain is that the cells in the adult brain do not generally divide and form new brain cells. There are a few exceptions, such as in the hippocampus, where new neurons can grow, but in most parts of the brain the changes that occur in response to a mental challenge—such as the contrast training used to improve people’s vision—won’t include the development of new neurons.