Is it possible that vaccinology has applied a reductionist—one disease, one drug/vaccine—model to an evolutionarily adapted system with built-in complexities we have barely begun to appreciate? Is it possible that we have misunderstood immunity, or are still fundamentally learning about its most basic principles? If we are to accept that billions of years have gone into priming our physiology for interface with microbes, then we must acknowledge that there is more to immunity than simply jacking up antibody levels. What is sound advice today may not be so sound tomorrow.
