catching or eating a delicious trout,1 and it will help you remember the following key features: T Tentative: Everything we think we know today is open to question and subject to reassessment, modification, or refutation. R Replication: Even the best studies are open to question and need to be replicated. O Observation: Knowledge is grounded in orderly and comprehensive observations. U Unbiased: Observations should be unbiased. T Transparency: All procedural details are openly specified for review and evaluation and to show the basis of conclusions that were reached.
