Common genetic variations affect the body’s ability to activate and use supplemental folic acid. L-5-methyltetrahydrofolate is the universally metabolized and active form, meaning it bypasses several enzymatic activation steps and is directly usable by the body, regardless of functional or genetic variations. I recommend reliable brands such as Thorne Research or Pure Encapsulations, in daily dosage of 400–800 mcg, to support adrenal health.
